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Since 1996, IHDN has successfully undertaken projects and programs for the benefit of the people of Ketu (North and South) and Keta Districts and surrounding areas in the southeastern part of Ghana.

IHDN MISSION HOSPITAL, now EP Church International Mission Hospital, first started clinical work under a mango tree Agbozume in 1996 and later opened a clinic called IHDN Family Health Clinic in the living room of the late Mr. Benjamin Agamah. Dr. Ransford Sefenu was the first medical officer hired for the clinic in 1998.

Dr. Sefenu promoted training and community health education through health broadcasts using the village public address system. He was able to raise awareness on malaria, hypertension, and diabetes. As of 2002, the clinic was treating over 5,000 patients each year. However, when the Sogakope Hospital was completed in January 2003, Dr. Sepenu was recruited, so the IHDN Family Health Clinic closed down.

Despite the closure of the clinic. Dr. Agamah still came to Ghana annually with medical teams. He went to the several villages from where patients, who previously attended the clinic before it closed down, came from. He held clinics in village classrooms. He was moved by the depth of poverty and plight of the communities. After praying and sharing with his family and friends, Dr. Agamah and his wife, June, committed to pursuing a bigger faith journey. They decided to use their personal savings to advance the work of IHDN in Ghana. In 2006 they acquired 23.5 acres of land at Weta-Adzadokpo, 3 miles from Agbozume, which they donated to IHDN to construct an ultra-modern medical facility.

Within two years, an Out-Patient Department (OPD) of IHDN Mission Hospital comprising 6 consulting rooms, a treatment room, an emergency ward, a surgical theater, a recovery ward, a laboratory, a designated X-ray room, administrative offices, guest apartments, and a conference room laboratory was completed at the cost of $850,000 and commissioned on June 14, 2008. In January 2018, the laboratory needed more space, so the X-ray room was converted to additional laboratory space.

As most of the patients were very ill and traveled from several miles away, an inpatient department (IPD) was needed. Accordingly, a 60-bed ward to help provide better care to the patients was built at a cost of $700,000. This was completed and commissioned on July 20, 2013. The addition of maternity wards in 2016 increased the bed capacity to 80.

IHDN Mission Hospital, now known as E. P. Church International Mission Hospital, membership with CHAG in 2016 was later withdrawn in 2017. However, having satisfied all relevant membership requirements, it was reinstated in 2024 and has been in good standing since.

The hospital provides medical and surgical care to over 30,000 clients yearly. The hospital serves a catchment area of over 120,000 people in the Anlo, Keta, & Ketu Municipalities and adjourning communities.